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OCD - 2 year old female kelpie x border collie constantly sniffing?

Our 2 year old de-sexed female kelpie x border collie has recently started obsessively sniffing everywhere inside the house. It started in just one area and now whenever she is inside she constantly walks around the house sniffing until she is exhausted. She has gone from being an in your face, social butterfly to not even acknowledging us or responding to treats and toys. Blood tests have come up with nothing, we don't have white ants. Vets are keen to just put her on medication, but we are willing to try other ideas before this. Can anyone help


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